3x3 Eyes is a story about a not so young girl (she is 300 years old but she keeps herself in such good shape!^_^!) named Pai who was the last of a mythical race called the 'sanjiyan'. They were powerful, immortal "monsters" with three eyes (a triclops) who used to roam the planet. With her is Yakumo Fujii, an ordinary highschool student who becomes her "Wu", an immortal servant of a sanjiyan, after Pai saves and then resurects him from death. Yakumo then joins Pai in her conquest to become human.